Dataset Information


Expression profiling of murine lung 70 days following exposure to fractionated or acute dose of 1.0 Gy 56Fe- particle irradiation

ABSTRACT: Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated controls or those irradiated with an acute dose. Microarray profiling was perfromed on whole lungs from K-rasLA1 mice in order to determine global expression changes in the lung following radiation exposure. RNA was extracted from K-rasLA1 lungs from unirradiated control animals or those irradiated with a fractionated or acute dose of 1.0Gy 56Fe- particles 70 days post-irradiation when lungs are still histologically indistiguishable and only contain benign lesions. 129S2 K-rasLA1 mice were either irradiated with an acute (1.0Gy x1; n = 15) or fractionated (0.2Gy x5; n=13) dose of 1.0Gy 56Fe- particles or left unirradiated (n=13). Animals were euthanized 70 days post-irradiation and RNA was extracted from the whole left lung of each animal.

ORGANISM(S): Mus musculus  

SUBMITTER: Kimberly Batten   Kimberly G Batten  Oliver Delgado  Jerry W Shay 

PROVIDER: E-GEOD-42233 | ArrayExpress | 2014-09-22



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Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer.

Delgado Oliver O   Batten Kimberly G KG   Richardson James A JA   Xie Xian-Jin XJ   Gazdar Adi F AF   Kaisani Aadil A AA   Girard Luc L   Behrens Carmen C   Suraokar Milind M   Fasciani Gail G   Wright Woodring E WE   Story Michael D MD   Wistuba Ignacio I II   Minna John D JD   Shay Jerry W JW  

Clinical cancer research : an official journal of the American Association for Cancer Research 20140131 6

Carcinogenesis is an adaptive process between nascent tumor cells and their microenvironment, including the modification of inflammatory responses from antitumorigenic to protumorigenic. Radiation exposure can stimulate inflammatory responses that inhibit or promote carcinogenesis. The purpose of this study is to determine the impact of radiation exposure on lung cancer progression in vivo and assess the relevance of this knowledge to human carcinogenesis.K-ras(LA1) mice were irradiated with var  ...[more]

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