Transcriptomics

Dataset Information

7

Transcriptional profiling of Ewing's sarcoma derived exosomes


ABSTRACT: Exosomes are small RNA and protein containing vesicles that can mediate hetero- and homotypic intercellular communication between normal and malignant cells. Especially, tumor-derived exosomes are believed to mediate reprogramming of the tumor-associated stroma to favor tumor growth and metastasis. In this study we isolated exosomes from three different Ewing’s sarcoma (ES) cell lines by ultracentrifugation. Microarray analysis of ES-derived exosomes and their parental cells was performed to gain insight into the spectrum of transcripts they contain and the functions in which these transcripts might be involved in. In total we analyzed six different samples consisting of three pairs of exosomal and cellular RNA of different Ewing's sarcoma cell lines.

ORGANISM(S): Homo sapiens  

SUBMITTER: Isabella V Miller   Guenther H Richter  Stefan Burdach  Thomas G Grunewald  Olivia P da Costa  Olivia Prazeres da Costa 

PROVIDER: E-GEOD-42282 | ArrayExpress | 2013-05-01

SECONDARY ACCESSION(S): GSE42282PRJNA179529

REPOSITORIES: GEO, ArrayExpress

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