Transcriptomics

Dataset Information

5

Methylation profiling classifies HIV-associated lymphoma


ABSTRACT: HIV-positive patients have a higher risk of non-Hodgkin's lymphoma with poor prognostic features. To characterize features of HIV-associated lymphoma, we compared the genome-wide DNA methylation profiles in between 11 HIV-associated and 20 non-HIV lymphoma samples by Illumina Infinium HumanMethylation450 BeadChip v1.0. Bisulfite-converted DNA from the 31 samples were analyzed to obtain the genome-wide methylation profile by using Illumina Infinium HumanMethylation450 BeadChip microarray.

ORGANISM(S): Homo sapiens  

SUBMITTER: Maria Yamazaki   Akihiro Matsunaga  Tsunekazu Hishima  Noriko Tanaka  Makoto Motizuki  Shotaro Hagiwara  Mari Shimura  Yukihito Ishizaka 

PROVIDER: E-GEOD-42372 | ArrayExpress | 2014-01-30

SECONDARY ACCESSION(S): GSE42372PRJNA181202

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications


BACKGROUND: HIV-positive patients have a 60-fold to 200-fold increased incidence of non-Hodgkin lymphomas, including Burkitt lymphoma, diffuse large B-cell lymphoma, and primary central nervous system lymphoma. HIV-associated lymphomas frequently have features such as extranodal involvement, decreased responses to standard chemotherapy, and high relapse rates, which indicate a poor prognosis. General pathological features do not clearly differentiate HIV-associated lymphomas from non-HIV lymphom  ...[more]

Similar Datasets

2013-06-01 | E-GEOD-32146 | ArrayExpress
2015-07-09 | E-GEOD-66552 | ArrayExpress
2012-04-04 | E-GEOD-32148 | ArrayExpress
2015-02-02 | E-GEOD-40576 | ArrayExpress
2013-06-12 | E-GEOD-44684 | ArrayExpress
2013-01-01 | E-GEOD-41384 | ArrayExpress
2015-05-19 | E-GEOD-65820 | ArrayExpress
2019-08-01 | E-MTAB-7183 | ArrayExpress
2016-04-01 | E-GEOD-70783 | ArrayExpress
2013-07-01 | E-GEOD-45958 | ArrayExpress