Dataset Information


Methylation profiling classifies HIV-associated lymphoma

ABSTRACT: HIV-positive patients have a higher risk of non-Hodgkin's lymphoma with poor prognostic features. To characterize features of HIV-associated lymphoma, we compared the genome-wide DNA methylation profiles in between 11 HIV-associated and 20 non-HIV lymphoma samples by Illumina Infinium HumanMethylation450 BeadChip v1.0. Bisulfite-converted DNA from the 31 samples were analyzed to obtain the genome-wide methylation profile by using Illumina Infinium HumanMethylation450 BeadChip microarray.

ORGANISM(S): Homo sapiens  

SUBMITTER: Maria Yamazaki   Akihiro Matsunaga  Tsunekazu Hishima  Noriko Tanaka  Makoto Motizuki  Shotaro Hagiwara  Mari Shimura  Yukihito Ishizaka 

PROVIDER: E-GEOD-42372 | ArrayExpress | 2014-01-30



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BACKGROUND: HIV-positive patients have a 60-fold to 200-fold increased incidence of non-Hodgkin lymphomas, including Burkitt lymphoma, diffuse large B-cell lymphoma, and primary central nervous system lymphoma. HIV-associated lymphomas frequently have features such as extranodal involvement, decreased responses to standard chemotherapy, and high relapse rates, which indicate a poor prognosis. General pathological features do not clearly differentiate HIV-associated lymphomas from non-HIV lymphom  ...[more]

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