Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA182001PRJNA182000PRJNA182002
ORGANISM(S): Rattus norvegicus
SUBMITTER: Yang Yu Ying Chen Qing R Lu
PROVIDER: E-GEOD-42447 | ArrayExpress | 2013-01-20
SECONDARY ACCESSION(S): SRP017276GSE42447PRJNA182002
REPOSITORIES: GEO, ArrayExpress, ENA
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E-GEOD-42447.idf.txt | Idf | |||
E-GEOD-42447.processed.1.zip | Processed | |||
E-GEOD-42447.sdrf.txt | Txt |
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Yu Yang Y Chen Ying Y Kim Bongwoo B Wang Haibo H Zhao Chuntao C He Xuelian X Liu Lei L Liu Wei W Wu Lai Man N LM Mao Meng M Chan Jonah R JR Wu Jiang J Lu Q Richard QR
Cell 20130101 1-2
Establishment of oligodendrocyte identity is crucial for subsequent events of myelination in the CNS. Here, we demonstrate that activation of ATP-dependent SWI/SNF chromatin-remodeling enzyme Smarca4/Brg1 at the differentiation onset is necessary and sufficient to initiate and promote oligodendrocyte lineage progression and maturation. Genome-wide multistage studies by ChIP-seq reveal that oligodendrocyte-lineage determination factor Olig2 functions as a prepatterning factor to direct Smarca4/Br ...[more]