Transcriptomics,Genomics

Dataset Information

239

Activation of the chromatin-remodeling factor Smarca4/Brg1 cooperates with Olig2 to establish oligodendrocyte identity and control CNS myelination


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Musculus  

SUBMITTER: Yang Yu  

PROVIDER: E-GEOD-42454 | ArrayExpress | 2013-01-20

SECONDARY ACCESSION(S): GSE42454PRJNA182000

REPOSITORIES: GEO, ArrayExpress

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Publications

Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation.

Yu Yang Y   Chen Ying Y   Kim Bongwoo B   Wang Haibo H   Zhao Chuntao C   He Xuelian X   Liu Lei L   Liu Wei W   Wu Lai Man N LM   Mao Meng M   Chan Jonah R JR   Wu Jiang J   Lu Q Richard QR  

Cell 20130101 1-2


Establishment of oligodendrocyte identity is crucial for subsequent events of myelination in the CNS. Here, we demonstrate that activation of ATP-dependent SWI/SNF chromatin-remodeling enzyme Smarca4/Brg1 at the differentiation onset is necessary and sufficient to initiate and promote oligodendrocyte lineage progression and maturation. Genome-wide multistage studies by ChIP-seq reveal that oligodendrocyte-lineage determination factor Olig2 functions as a prepatterning factor to direct Smarca4/Br  ...[more]

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