Transcriptomics

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Induced pluripotent stem cell-derived neurons from a sporadic Alzheimer disease donor as a model for investigating disease mechanisms


ABSTRACT: Gene expression analysis of control fibroblasts (NFH2), one AD-derived fibroblasts (NFH-46), NFH2-derived control-iPS cells (OiPS3, OiPS6), NFH46-derived AD-iPS cells (iPS5 and iPS 26B), hESCs (H1 and H9). Total mRNA obtained from AD fibroblasts (NFH-46) and control fibroblasts (NFH-2), from pluripotent stem cells AD-iPS cells (iPS5 and iPS 26B), control-iPS cells (OiPS3, OiPS6), and hESCs (H1 and H9).

ORGANISM(S): Homo sapiens  

SUBMITTER: Alessandro Prigione   

PROVIDER: E-GEOD-42492 | ArrayExpress | 2015-04-21

SECONDARY ACCESSION(S): GSE42492PRJNA182145

REPOSITORIES: GEO, ArrayExpress

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Publications

Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks.

Hossini Amir M AM   Megges Matthias M   Prigione Alessandro A   Lichtner Bjoern B   Toliat Mohammad R MR   Wruck Wasco W   Schröter Friederike F   Nuernberg Peter P   Kroll Hartmut H   Makrantonaki Eugenia E   Zouboulis Christos C CC   Adjaye James J  

BMC genomics 20150214


Alzheimer's disease (AD) is a complex, irreversible neurodegenerative disorder. At present there are neither reliable markers to diagnose AD at an early stage nor therapy. To investigate underlying disease mechanisms, induced pluripotent stem cells (iPSCs) allow the generation of patient-derived neuronal cells in a dish.In this study, employing iPS technology, we derived and characterized iPSCs from dermal fibroblasts of an 82-year-old female patient affected by sporadic AD. The AD-iPSCs were di  ...[more]

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