Transcriptomics

Dataset Information

9

Cluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy


ABSTRACT: Overall, the widely disparate transcriptomes identified prior to RT among the three clusters support the notion that at least some of the inter-individual heterogeneity in propensity for RT-induced myofiber hypertrophy is likely pre-determined. Baseline comparisons of skeletal muscle transcript profiles from 44 subjects previously clustered (K-means cluster analysis) as non-, modest-, and extreme-responders (Non, n=15; Mod, n=14; Xtr, n=15) based on the magnitudes of change in vastus lateralis myofiber cross-sectional area (CSA) following 16-wk, 3-d/wk, high-intensity RT.

ORGANISM(S): Homo sapiens  

SUBMITTER: James Cross   Samuel Windham  Michael Stec  Marcas Bamman  Xiangqin Cui  Anna Thalacker-Mercer 

PROVIDER: E-GEOD-42507 | ArrayExpress | 2013-05-24

SECONDARY ACCESSION(S): GSE42507PRJNA182183

REPOSITORIES: GEO, ArrayExpress

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Publications

Cluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy.

Thalacker-Mercer Anna A   Stec Michael M   Cui Xiangqin X   Cross James J   Windham Samuel S   Bamman Marcas M  

Physiological genomics 20130430 12


Using genomic microarray analysis, we sought to identify and annotate differences in the pretraining skeletal muscle transcriptomes among human subjects clustered as nonresponders (Non), modest responders (Mod), and extreme responders (Xtr) based on differential magnitudes of myofiber hypertrophy in response to progressive resistance training (RT) (Non-6 μm², Mod 1,111 μm², or Xtr 2,475 μm²). In prior work, we noted differences among clusters in the prevalence of myogenic stem cells prior to and  ...[more]

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