Transcriptomics

Dataset Information

10

Lactobacillus acidophilus and Helicobacter pylori stimulation of bone marrow derived macrophage


ABSTRACT: Helicobacter pylori causes chronic gastritis and avoids elimination by the immune system of the infected host. The commensal bacterium Lactobacillus acidophilus has been reported to exert beneficial effects as a supplement during H. pylori eradication therapy. In the present study, we applied whole genome microarray analysis to compare the immune response induced in murine bone marrow derived macrophages (BMDM) stimulated with L. acidophilus, H. pylori, or with both bacteria in combination Microarray expression profiling was performed to analyze stimulation of bone marrow derived macrophages with Helicobacter pylori 251, Lactobacillus acidophilus NCFM or Lactobacillus acidophilus NCFM co-stimulated with Helicobacter pylori 251 were analyzed 5 hours after infection.

ORGANISM(S): Mus musculus  

SUBMITTER: Jodee Gould   Sam Forster  Paul Hertzog  Maria Kaparakis-Liaskos  Gudrun Weiss 

PROVIDER: E-GEOD-42622 | ArrayExpress | 2013-07-02

SECONDARY ACCESSION(S): GSE42622PRJNA182370

REPOSITORIES: GEO, ArrayExpress

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Publications

Helicobacter pylori VacA suppresses Lactobacillus acidophilus-induced interferon beta signaling in macrophages via alterations in the endocytic pathway.

Weiss Gudrun G   Forster Sam S   Irving Aaron A   Tate Michelle M   Ferrero Richard L RL   Hertzog Paul P   Frøkiær Hanne H   Kaparakis-Liaskos Maria M  

mBio 20130611 3


Helicobacter pylori causes chronic gastritis and avoids elimination by the immune system of the infected host. The commensal bacterium Lactobacillus acidophilus has been suggested to exert beneficial effects as a supplement during H. pylori eradication therapy. In the present study, we applied whole-genome microarray analysis to compare the immune responses induced in murine bone marrow-derived macrophages (BMDMs) stimulated with L. acidophilus, H. pylori, or both bacteria in combination. While  ...[more]

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