Transcriptomics

Dataset Information

295

Transcription profiling of human high-grade astrocytomas reveals prognostic subgroups


ABSTRACT: Novel prognostic subclasses of high-grade astrocytoma are identified and discovered to resemble stages in neurogenesis. One tumor class displaying neuronal lineage markers shows longer survival, while two tumor classes enriched for neural stem cell markers display equally short survival. Poor prognosis subclasses exhibit either markers of proliferation or of angiogenesis and mesenchyme. Analysis of gene expression data is described in Phillips et al., Cancer Cell, 2006. Experiment Overall Design: 77 primary high-grade astrocytomas and 23 matched recurrences were profiled to identify changes in gene expression that relate to both survival and disease progression. Samples include WHO grade III and IV astrocytomas with a wide range of survival times.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

DISEASE(S): Astrocytoma

SUBMITTER: Thomas D. Wu   

PROVIDER: E-GEOD-4271 | ArrayExpress| 2012-03-27

SECONDARY ACCESSION(S): GSE4271GDS1815GDS1816PRJNA94953

REPOSITORIES: GEO, ArrayExpress

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Publications

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.

Phillips Heidi S HS   Kharbanda Samir S   Chen Ruihuan R   Forrest William F WF   Soriano Robert H RH   Wu Thomas D TD   Misra Anjan A   Nigro Janice M JM   Colman Howard H   Soroceanu Liliana L   Williams P Mickey PM   Modrusan Zora Z   Feuerstein Burt G BG   Aldape Ken K  

Cancer cell 20060301 3


Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and discovered to resemble stages in neurogenesis. One tumor class displaying neuronal lineage markers shows longer survival, while two tumor classes enriched for neural stem cell markers display equally short survival. Poor prognosis subclasses exhibit markers either of proliferation or of angiogenesis and mesenchyme. Upon recurrence, tumors frequently shift toward the mesenchymal subclass. Chromosomal locatio  ...[more]

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