Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA184341
ORGANISM(S): Mus Musculus
SUBMITTER: Markus Jaritz Anja Ebert Hiromi Tagoh Jasna Medvedovic Meinrad Busslinger
PROVIDER: E-GEOD-43008 | ArrayExpress | 2013-09-30
SECONDARY ACCESSION(S): GSE43008SRP017609PRJNA184341
REPOSITORIES: GEO, ArrayExpress, ENA
Action | DRS | |||
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E-GEOD-43008.additional.1.zip | Other | |||
E-GEOD-43008.idf.txt | Idf | |||
E-GEOD-43008.processed.1.zip | Processed | |||
E-GEOD-43008.processed.10.zip | Processed | |||
E-GEOD-43008.processed.11.zip | Processed |
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Immunity 20130801 2
The immunoglobulin heavy-chain (Igh) locus undergoes large-scale contraction in pro-B cells, which facilitates VH-DJH recombination by juxtaposing distal VH genes next to the DJH-rearranged gene segment in the 3' proximal Igh domain. By using high-resolution mapping of long-range interactions, we demonstrate that local interaction domains established the three-dimensional structure of the extended Igh locus in lymphoid progenitors. In pro-B cells, these local domains engaged in long-range intera ...[more]