Transcriptomics

Dataset Information

309

Gene Expression Defines Natural Changes in Mammalian Lifespan


ABSTRACT: Mammals differ more than hundred fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney and brain of 33 diverse species of mammals. Our analysis uncovered parallel evolution of gene expression and lifespan, as well as the associated life history traits, and identified the processes and pathways involved. These findings provide direct insights into how Nature reversibly adjusts lifespan and other traits during adaptive radiation of lineages. RNA-seq gene expression profiling in normal liver, kidney and brain of 33 mammalian species.

SUBMITTER: Alexey V Lobanov   Alexey Fushan  Alexey A Fushan  Vadim N Gladyshev  Sun H Yim  Eun B Kim  Anton A Turanov  Sang G Lee 

PROVIDER: E-GEOD-43013 | ArrayExpress | 2015-02-17

SECONDARY ACCESSION(S): GSE43013SRP017611PRJNA184055

REPOSITORIES: GEO, ArrayExpress, ENA

altmetric image

Publications


Mammals differ more than 100-fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney, and brain of 33 diverse species of mammals. Our  ...[more]

Similar Datasets

2013-12-04 | E-GEOD-45569 | ArrayExpress
2012-04-04 | E-MTAB-1069 | ArrayExpress
2012-04-04 | E-MTAB-1070 | ArrayExpress
2013-08-30 | E-MTAB-1748 | ArrayExpress
2016-07-01 | E-GEOD-81949 | ArrayExpress
2016-07-01 | E-GEOD-80057 | ArrayExpress
2014-04-10 | E-MTAB-2301 | ArrayExpress
2013-04-11 | E-GEOD-45277 | ArrayExpress
2015-01-08 | E-GEOD-53988 | ArrayExpress
2016-02-12 | E-GEOD-64834 | ArrayExpress