Dataset Information


Transcriptional profiles of Campylobacter jejuni NCTC 11168 to 4mg/L erythromycin treatment

ABSTRACT: Erythromycin is the drug of choice to treat campylobacteriosis, but resistance to this antibiotic is rising. The adaptive mechanisms employed by Campylobacter jejuni to erythromycin treatment remain unknown. The aim of this study is to determine the molecular basis underlying Campylobacter’s immediate response to Ery treatment. The design utilized an available two color microarray slide for the entire transcriptome of Campylobacter jejuni wild type strain NCTC 11168. One hybridizations were performed: sham-treated NCTC 11168 v.s. lethal dose erythromycin treated NCTC 11168. Samples were independently grown and harvested. There were three biological replicates of each sample.

ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819  

SUBMITTER: Zuowei Wu   Qijing Zhang  Qingqing Xia 

PROVIDER: E-GEOD-43023 | ArrayExpress | 2013-10-10



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Adaptive mechanisms of Campylobacter jejuni to erythromycin treatment.

Xia Qingqing Q   Muraoka Wayne T WT   Shen Zhangqi Z   Sahin Orhan O   Wang Hongning H   Wu Zuowei Z   Liu Peng P   Zhang Qijing Q  

BMC microbiology 20130614

Macrolide is the drug of choice to treat human campylobacteriosis, but Campylobacter resistance to this antibiotic is rising. The mechanisms employed by Campylobacter jejuni to adapt to erythromycin treatment remain unknown and are examined in this study. The transcriptomic response of C. jejuni NCTC 11168 to erythromycin (Ery) treatment was determined by competitive microarray hybridizations. Representative genes identified to be differentially expressed were further characterized by constructi  ...[more]

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