Transcriptomics,Multiomics

Dataset Information

3

Hypoxia-induced miR-210 modulates gene expression in response to acute peripheral ischemia.


ABSTRACT: Peripheral Artery Disease is caused by the restriction or occlusion of arteries supplying the leg. Better understanding of the molecular mechanisms underpinning tissue response to acute and chronic ischemia is urgently needed to improve therapeutic options. The aim of this study is understanding miR-210 regulation and role in a mouse model of hindlimb ischemia. To investigate miR-210 function, mice were injected with a miR-210 complementary LNA-oligonucleotide (anti-miR-210). Then, the left femoral artery was dissected in order to induce unilateral hindlimb ischemia. Mice were sacrified 3 days later and gene expression profiles of gastrocnemius muscles were obatained.

OTHER RELATED OMICS DATASETS IN: PRJNA185485

ORGANISM(S): Mus Musculus

SUBMITTER: Germana Zaccagnini   Biagina Maimone  Pasquale Fasanaro  Fabio Martelli 

PROVIDER: E-GEOD-43340 | ArrayExpress | 2015-10-23

SECONDARY ACCESSION(S): GSE43340PRJNA185485

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-43340.additional.1.zip Other
E-GEOD-43340.idf.txt Idf
E-GEOD-43340.processed.1.zip Processed
E-GEOD-43340.sdrf.txt Txt
Items per page:
1 - 4 of 4
altmetric image

Publications

Hypoxia-induced miR-210 modulates tissue response to acute peripheral ischemia.

Zaccagnini Germana G   Maimone Biagina B   Di Stefano Valeria V   Fasanaro Pasquale P   Greco Simona S   Perfetti Alessandra A   Capogrossi Maurizio C MC   Gaetano Carlo C   Martelli Fabio F  

Antioxidants & redox signaling 20131016 8


<h4>Aims</h4>Peripheral artery disease is caused by the restriction or occlusion of arteries supplying the leg. Better understanding of the molecular mechanisms underpinning tissue response to ischemia is urgently needed to improve therapeutic options. The aim of this study is to investigate hypoxia-induced miR-210 regulation and its role in a mouse model of hindlimb ischemia.<h4>Results</h4>miR-210 expression was induced by femoral artery dissection. To study the role of miR-210, its function w  ...[more]

Similar Datasets

2015-01-01 | E-GEOD-35365 | ArrayExpress
2009-11-07 | E-GEOD-16962 | ArrayExpress
| E-GEOD-43340 | BioStudies
| S-EPMC5573334 | BioStudies
| GSE43340 | GEO
| S-EPMC6981725 | BioStudies
| S-EPMC8088433 | BioStudies
2015-04-06 | E-GEOD-56854 | ArrayExpress
2021-09-09 | PXD019992 | Pride
| S-EPMC4142832 | BioStudies