Transcriptomics,Multiomics

Dataset Information

64

Gene expression profiling of lung adenocarcinomas and normal lung tissue


ABSTRACT: Lung cancer is still the leading cause of cancer-related deaths in the US and worldwide. Understanding the global molecular profiles or transcriptome of lung cancers would strengthen our understanding of the biology of this malignancy. We performed gene expression profiling using the Human Gene 1.0 ST platform of 80 lung adenocarcinomas and 30 normal lung tissues to better understand the biology of this significant fraction of non-small cell lung carcinomas (NSCLCs) Lung adenocarcinomas were comrpised of never-smoker (n=40) and smoker (n=40) adenocarcinomas. Normal lung tissue (n=30) were paired to 30 of the never-smoker cases. Gene expression profiling was performed on the samples to identify differentially expressed profiles between lung adenocarcinomas and normal lung tissues.

REANALYSED by: E-GEOD-43458

OTHER RELATED OMICS DATASETS IN: E-GEOD-43459

ORGANISM(S): Homo sapiens  

SUBMITTER: Ignacio I Wistuba  Mohamed Kabbout   Humam Kadara    

PROVIDER: E-GEOD-43458 | ArrayExpress| 2015-08-19

SECONDARY ACCESSION(S): GSE43458PRJNA186452

REPOSITORIES: GEO, ArrayExpress

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Publications

ETS2 mediated tumor suppressive function and MET oncogene inhibition in human non-small cell lung cancer.

Kabbout Mohamed M   Garcia Melinda M MM   Fujimoto Junya J   Liu Diane D DD   Woods Denise D   Chow Chi-Wan CW   Mendoza Gabriela G   Momin Amin A AA   James Brian P BP   Solis Luisa L   Behrens Carmen C   Lee J Jack JJ   Wistuba Ignacio I II   Kadara Humam H  

Clinical cancer research : an official journal of the American Association for Cancer Research 20130509 13


The ETS2 transcription factor is an evolutionarily conserved gene that is deregulated in cancer. We analyzed the transcriptome of lung adenocarcinomas and normal lung tissue by expression profiling and found that ETS2 was significantly downregulated in adenocarcinomas. In this study, we probed the yet unknown functional role of ETS2 in lung cancer pathogenesis.Lung adenocarcinomas (n = 80) and normal lung tissues (n = 30) were profiled using the Affymetrix Human Gene 1.0 ST platform. Immunohisto  ...[more]

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