Transcriptomics,Multiomics

Dataset Information

2

Estrogen Induced DNA Methylation Changes in Mouse Hippocampus


ABSTRACT: Estrogen, specifically estradiol, has been shown to mediate DNA methylation changes at mutiple locations downstream of estrogen response elements (EREs). We identified differentially methylated regions associated with long-term estradiol exposure in the hippocampus of C57BL/6J mice. Hippocampus was collected from ovariectomized (OVX) C57BL/6J mice treated with estradiol (n=5) and vehicle controls (n=5). Genomic DNA was extracted and treated with methylation sensitive restriction enzymes HpaII and HinP1I to enrich for the unmethylated fraction. This fraction was interrogated using the Affymetrix GeneChip® Mouse Tiling Promoter 1.0R Array

OTHER RELATED OMICS DATASETS IN: PRJNA188772PRJNA186454

ORGANISM(S): Mus musculus  

SUBMITTER: Todd Gould   Jerry Guintivano  Michal Arad  Zachary Kaminsky 

PROVIDER: E-GEOD-43460 | ArrayExpress | 2013-05-24

SECONDARY ACCESSION(S): GSE43460PRJNA186454

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-43460.additional.1.zip Other
E-GEOD-43460.idf.txt Idf
E-GEOD-43460.raw.1.zip Raw
E-GEOD-43460.sdrf.txt Txt
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Publications

Antenatal prediction of postpartum depression with blood DNA methylation biomarkers.

Guintivano J J   Arad M M   Gould T D TD   Payne J L JL   Kaminsky Z A ZA  

Molecular psychiatry 20130521 5


Postpartum depression (PPD) affects ∼10-18% of women in the general population and results in serious consequences to both the mother and offspring. We hypothesized that predisposition to PPD risk is due to an altered sensitivity to estrogen-mediated epigenetic changes that act in a cell autonomous manner detectable in the blood. We investigated estrogen-mediated epigenetic reprogramming events in the hippocampus and risk to PPD using a cross-species translational design. DNA methylation profile  ...[more]

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