Transcriptomics

Dataset Information

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Microarray analysis of dorsal motor vagal nucleus, locus coeruleus and substantia nigra from postmortem samples of idiopathic Parkinson's disease patients in Braak stages 4-5


ABSTRACT: We analyzed the transcriptomic profile of post-mortem explants from dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra obtained from controls and Braak 4 (BK4) and 5 (BK5) stages of Parkinson’s disease (PD) patients in order to investigate how gene-gene interaction patterns vary along different anatomical regions in patients and controls. The comparative transcriptional networks analyses indicate that the main hubs in PD networks are related to ubquitin/proteasome, oxidative stress, neuroprotection, neurogenesis and PD associated proteins. Transcriptomic profiles of controls and Parkinson’s disease patients were compared using SAM test for LC or Wilcoxon Mann-Whitney test for SN and VA (p<0.005 and p<0.01, respectively) in order to identify differentially expressed transcripts.

ORGANISM(S): Homo sapiens  

SUBMITTER: Lea T Grinberg  Beatriz R Corradini   Jose M Farfel   Carlos Alberto Moreira-Filho   Priscila Iamashita   Carlos A Moreira-Filho   Edilaine Tampellini    

PROVIDER: E-GEOD-43490 | ArrayExpress| 2018-03-07

SECONDARY ACCESSION(S): GSE43490PRJNA186561

REPOSITORIES: GEO, ArrayExpress

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Publications

Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra.

Corradini Beatriz Raposo BR   Iamashita Priscila P   Tampellini Edilaine E   Farfel José Marcelo JM   Grinberg Lea Tenenholz LT   Moreira-Filho Carlos Alberto CA  

BioMed research international 20141126


Parkinson's disease (PD)—classically characterized by severe loss of dopaminergic neurons in the substantia nigra pars compacta—has a caudal-rostral progression, beginning in the dorsal motor vagal nucleus and, in a less extent, in the olfactory system, progressing to the midbrain and eventually to the basal forebrain and the neocortex. About 90% of the cases are idiopathic. To study the molecular mechanisms involved in idiopathic PD we conducted a comparative study of transcriptional interactio  ...[more]

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