Dataset Information


Effector cell signatures in peripheral blood after nasal allergen challenge: biomarkers of the allergic response

ABSTRACT: This study investigated temporal transcriptomic changes in response to nasal allergen challenge of titrated timothy grass pollen. This is an open single-center observational study conducted outside the pollen season. Twelve participants with seasonal allergic rhinitis underwent a control (diluent) challenge followed by nasal allergen challenge after an interval of 14 days. On each challenge day, nasal challenge with control or titrated timothy grass pollen (Aquagen, phleum pratense; ALK) was administered. Peripheral blood was collected before nasal challenge (baseline) and at 3, 6 and 24 hours following challenge. RNA was extracted from whole blood and CD4 cells for microarray experiment using Affymetrix Human Gene 1.0 ST arrays.

ORGANISM(S): Homo sapiens  

SUBMITTER: Moises A Calderon   Zhong Gao  Mohamed H Shamji  Janice A Layhadi  Deborah Phippard  Alkis Togias  Adam Asare  Sai krishna Kanaparthi  Laurence A Turka  Stephen R Durham  Guy W Scadding  Delica K Cheung  Virginia Bellido 

PROVIDER: E-GEOD-43497 | ArrayExpress | 2013-01-16



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