Transcriptomics,Multiomics

Dataset Information

40

Expression profiling of human medulloblastoma cell line ONS76 upon siRNA-mediated knockdown of KDM5A/LSD1


ABSTRACT: KDM5A/LSD1 is an important epigenetic regulator in medulloblastoma, the most frequent brain tumor of childhood. Here, the response of ONS76 medulloblastoma cells upon siRNA-mediated knockdown of KDM5A is analysed. The expression profile of ONS76 cells upon KDM5A knockdown was compared to mock control. Both conditions were run in triplicate.

REANALYSED by: E-GEOD-43552

ORGANISM(S): Homo sapiens  

SUBMITTER: Alexander Schramm  Kristian Pajtler    

PROVIDER: E-GEOD-43552 | ArrayExpress | 2015-08-19

SECONDARY ACCESSION(S): GSE43552PRJNA186703

REPOSITORIES: GEO, ArrayExpress

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Publications


BACKGROUND: Medulloblastoma is a leading cause of childhood cancer-related deaths. Current aggressive treatments frequently lead to cognitive and neurological disabilities in survivors. Novel targeted therapies are required to improve outcome in high-risk medulloblastoma patients and quality of life of survivors. Targeting enzymes controlling epigenetic alterations is a promising approach recently bolstered by the identification of mutations in histone demethylating enzymes in medulloblastoma se  ...[more]

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