Dataset Information


Gene expression profiling in cumulus cells (CC) derived from a modified natural and stimulated in vitro fertilization (IVF) procedures

ABSTRACT: Cumulus cells surrounding mature oocytes that developed to moruale/blastocyst stage on day 5 of IVF cycle were collected and used for gene expression profiling using Affymetrix Human Gene 1.0 ST Arrays in order to determine differences in gene expression between the modified natural and stimulated in vitro fertilization (IVF) procedures. Microarray analysis was made on 8 individual CC samples, derived from 5 patients that first underwent MNIVF, followed by a controlled ovarian hyperstimulation (COH) cycle. As the quality of the isolated RNA derived from 2 of the MNIVF CC samples was not good, these samples were not included in the analysis. Altogether, 3 CC samples from MNIVF and 5 CC samples from COH cycles were included in microarray analysis.

ORGANISM(S): Homo sapiens  

SUBMITTER: Peter Juvan   Tanja Burnik Papler  Irma Virant Klun  Klementina Fon Tacer  Rok Devjak  Eda Vrtačnik Bokal 

PROVIDER: E-GEOD-43684 | ArrayExpress | 2014-01-10



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Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles.

Papler Tanja Burnik TB   Bokal Eda Vrtačnik EV   Tacer Klementina Fon KF   Juvan Peter P   Virant Klun Irma I   Devjak Rok R  

Journal of assisted reproduction and genetics 20131113 1

PURPOSE: The aim of our study was to determine whether there are any differences in the cumulus cell gene expression profile of mature oocytes derived from modified natural IVF and controlled ovarian hyperstimulation cycles and if these changes could help us understand why modified natural IVF has lower success rates. METHODS: Cumulus cells surrounding mature oocytes that developed to morulae or blastocysts on day 5 after oocyte retrieval were submitted to microarray analysis. The obtained data  ...[more]

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