Transcriptomics

Dataset Information

120

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (expression)


ABSTRACT: Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. We have examined the effect of suppressing the histone demethylases Jarid1a and Jarid1b on the senescence-associated gene expression signatures. Human fibroblast (IMR90) cells were infected with retroviral vectors expresssing shRNA targeting Jarid1a, Jarid1b or both, and triggered to undergo quiescence by removal of serum or senescence by over-expression of activated ras (Hrasv12).

ORGANISM(S): Homo sapiens  

SUBMITTER: Xiaowo Wang   Agustin Chicas  Scott W Lowe 

PROVIDER: E-GEOD-43920 | ArrayExpress | 2013-01-31

SECONDARY ACCESSION(S): GSE43920PRJNA188185

REPOSITORIES: GEO, ArrayExpress

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Publications

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.

Chicas Agustin A   Kapoor Avnish A   Wang Xiaowo X   Aksoy Ozlem O   Evertts Adam G AG   Zhang Michael Q MQ   Garcia Benjamin A BA   Bernstein Emily E   Lowe Scott W SW  

Proceedings of the National Academy of Sciences of the United States of America 20120521 23


Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. Here we combine quantitative mass spectrometry, ChIP deep-sequencing, and functional studies to determine the role of histone modifications on chromatin structure and gene-expression alterations associated with senescence in primary human cells. We uncover distinct senescence-associated changes in histone-modification pa  ...[more]

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