Transcriptomics

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C/EBPa gene signature


ABSTRACT: We defined the C/EBPa signature characterized by a set of genes which are upregulated upon C/EBPa activation. In order to identify the C/EBPa signature, we performed microarray gene expression analysis of K562 cells stably expressing p42-C/EBPa-ER after activating the C/EBPa construct to translocate to the nucleus for 6 hours with beta-estradiol. The gene expression profile was performed in K562 p42-C/EBPa-ER expressing cells treated with beta-estradiol (n=4) or EtOH vehicle control (n-4) for 6 hours. Induction of nuclear localization of C/EBPa-ER fusion protein was achieved by addition of 1 uM beta-estradiol as indicated into the culture medium.

ORGANISM(S): Homo sapiens  

SUBMITTER: Ruud Delwel  Patrick Tan   Chen Ju   Mengchu Wu   Touati Benoukraf   Adam L Liss   Meritxell Alberich-Jordà   Martin Balastik   Chia H Ooi   Daniel G Tenen   Tomas Brdicka   Hanna Radomska   Polina Zjablovskaja    

PROVIDER: E-GEOD-43998 | ArrayExpress | 2013-04-01

SECONDARY ACCESSION(S): GSE43998PRJNA188317

REPOSITORIES: GEO, ArrayExpress

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