Transcriptomics,Multiomics

Dataset Information

4

Expression data from Sh2b3 Knock-out NOTCH1-induced leukemias


ABSTRACT: To formally address the tumor suppressor activity of Sh2b3 in vivo, we tested the interaction between oncogenic NOTCH1 and Sh2b3 loss in a retroviral- transduction bone marrow transplantation model of NOTCH-induced T-ALL Forced expression of activated NOTCH1 in this model typically results in full leukemia transformation 5-10 weeks later. We performed microarray gene expression analysis of Sh2b3 wild type and Sh2b3–/– NOTCH1 induced leukemias

OTHER RELATED OMICS DATASETS IN: PRJNA188332

ORGANISM(S): Mus musculus  

SUBMITTER: Jacob M Rowe   Kara Kelly  Elisabeth Paietta  Wendy K Chung  Wei Tong  Giuseppe Basso  Michael Hadler  Arianne Perez-Garcia  Isaura Rigo  Charles A LeDuc  Adolfo A Ferrando  Janis Racevskis  Martin S Tallman  Chaim Jalas  Maddalena Paganin  Alberto Ambesi-Impiombato 

PROVIDER: E-GEOD-44025 | ArrayExpress | 2013-11-06

SECONDARY ACCESSION(S): GSE44025PRJNA188332

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-44025.idf.txt Idf
E-GEOD-44025.processed.1.zip Processed
E-GEOD-44025.raw.1.zip Raw
E-GEOD-44025.sdrf.txt Txt
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Publications


The SH2B adaptor protein 3 (SH2B3) gene encodes a negative regulator of cytokine signaling with a critical role in the homeostasis of hematopoietic stem cells and lymphoid progenitors. Here, we report the identification of germline homozygous SH2B3 mutations in 2 siblings affected with developmental delay and autoimmunity, one in whom B-precursor acute lymphoblastic leukemia (ALL) developed. Mechanistically, loss of SH2B3 increases Janus kinase-signal transducer and activator of transcription si  ...[more]

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