Transcriptomics,Genomics,Multiomics

Dataset Information

60

TET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: CHUNLEI JIN   

PROVIDER: E-GEOD-44039 | ArrayExpress | 2014-06-06

SECONDARY ACCESSION(S): GSE44039PRJNA188407

REPOSITORIES: GEO, ArrayExpress

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Publications

TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells.

Jin Chunlei C   Lu Yue Y   Jelinek Jaroslav J   Liang Shoudan S   Estecio Marcos R H MR   Barton Michelle Craig MC   Issa Jean-Pierre J JP  

Nucleic acids research 20140529 11


TET1 is a 5-methylcytosine dioxygenase and its DNA demethylating activity has been implicated in pluripotency and reprogramming. However, the precise role of TET1 in DNA methylation regulation outside of developmental reprogramming is still unclear. Here, we show that overexpression of the TET1 catalytic domain but not full length TET1 (TET1-FL) induces massive global DNA demethylation in differentiated cells. Genome-wide mapping reveals that 5-hydroxymethylcytosine production by TET1-FL is inhi  ...[more]

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