Dataset Information


EMT-induced stemness and tumorigenicity are fueled by an oncogenic EGF/Ras pathway

ABSTRACT: Pre-EMT GIF14 cells treated with TGF-β1 Total RNA obtained from isolated GIF-14 cells from untreated and TGF-β1-treated sample

ORGANISM(S): Mus musculus  

SUBMITTER: Dominic C Voon   Tuan Zea Tan  Tony T Tan  Yoshiaki Ito  Jason K Koo 

PROVIDER: E-GEOD-44055 | ArrayExpress | 2014-02-19



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EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway.

Voon Dominic Chih-Cheng DC   Wang Huajing H   Koo Jason Kin Wai JK   Chai Juin Hsien JH   Hor Yit Teng YT   Tan Tuan Zea TZ   Chu Yeh-Shiu YS   Mori Seiichi S   Ito Yoshiaki Y  

PloS one 20130812 8

Recent studies have revealed that differentiated epithelial cells would acquire stem cell-like and tumorigenic properties following an Epithelial-Mesenchymal Transition (EMT). However, the signaling pathways that participate in this novel mechanism of tumorigenesis have not been fully characterized. In Runx3 (-/-) p53 (-/-) murine gastric epithelial (GIF-14) cells, EMT-induced plasticity is reflected in the expression of the embryonal proto-oncogene Hmga2 and Lgr5, an exclusive gastrointestinal  ...[more]

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