Dataset Information


KRAB/KAP1-microRNA cascade regulates erythropoiesis through the stage-specific control of mitophagy [Seq]

ABSTRACT: A multilayered transcription regulatory system is unveiled, where protein- and RNA-based repressors are super-imposed in combinatorial fashion to govern the timely triggering of an essential step of erythropoiesis Analyses of transcriptional profiles and chromatin state in KAP1 WT and KO (or KD) cells

ORGANISM(S): Musculus  

SUBMITTER: Isabelle Barde   Andrea Corsinotti  Didier Trono  Jiri Vanicek  Sandra Offner  Benjamin Rauwel  Julien Marquis  Elisa Laurenti  Ray M Marin-Florez  Sonia Verp  Adamandia Kapopoulou 

PROVIDER: E-GEOD-44061 | ArrayExpress | 2013-04-03



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A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy.

Barde Isabelle I   Rauwel Benjamin B   Marin-Florez Ray Marcel RM   Corsinotti Andrea A   Laurenti Elisa E   Verp Sonia S   Offner Sandra S   Marquis Julien J   Kapopoulou Adamandia A   Vanicek Jiri J   Trono Didier D  

Science (New York, N.Y.) 20130314 6130

During hematopoiesis, lineage- and stage-specific transcription factors work in concert with chromatin modifiers to direct the differentiation of all blood cells. We explored the role of KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofactor KAP1 in this process. In mice, hematopoietic-restricted deletion of Kap1 resulted in severe hypoproliferative anemia. Kap1-deleted erythroblasts failed to induce mitophagy-associated genes and retained mitochondria. This was due to persistent ex  ...[more]

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