Dataset Information


Liver X Receptors play an antitumoral role in the intestine

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Musculus  

SUBMITTER: Antonio Moschetta  

PROVIDER: E-GEOD-44073 | ArrayExpress | 2013-02-05



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Liver X receptors inhibit proliferation of human colorectal cancer cells and growth of intestinal tumors in mice.

Lo Sasso Giuseppe G   Bovenga Fabiola F   Murzilli Stefania S   Salvatore Lorena L   Di Tullio Giuseppe G   Martelli Nicola N   D'Orazio Andria A   Rainaldi Stefania S   Vacca Michele M   Mangia Anita A   Palasciano Giuseppe G   Moschetta Antonio A  

Gastroenterology 20130216 7

Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated whether expression of activated LXR protects against intestinal tumorigenesis in mice.We analyzed the development of colon cancer in mice that express a constitutive active form of LXRα only in the  ...[more]

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