Genomics

Dataset Information

5

Gene expression profile analysis of mouse whole spleen following infection by lymphocytic choriomeningitis virus (LCMV), comparing LCMV-Armstrong and LCMV-Clone 13 expression patterns at 0, 5, 9, and 30 days


ABSTRACT: To identify mechanisms behind immunosuppression during virus infections, we infected mice with LCMV-Armstrong and LCMV-Clone 13 expression patterns. LCMV-Armstrong induces a T-cell reaction that resolves infection within 8-10 days, while LCMV-Clone13 generates a persisten infection through immunosuppression. We used microarray to uncover splenic gene expression patterns specific to each LCMV infection at 5, 9, and 30 days C57BL6 mice, 6-10 weeks old, were infected with LCMV-Armstrong and LCMV-Clone 13 or left uninfected (naïve). At days 5, 9, and 30 whole spleens were harvested for RNA extraction and hybridization on Affymetric microarray.

ORGANISM(S): Mus musculus  

SUBMITTER: Bruce Aronow   David Brooks  Rebekah Karns 

PROVIDER: E-GEOD-44322 | ArrayExpress | 2013-02-15

SECONDARY ACCESSION(S): GSE44322PRJNA189457

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-44322.idf.txt Idf
E-GEOD-44322.processed.1.zip Processed
E-GEOD-44322.raw.1.zip Raw
E-GEOD-44322.sdrf.txt Txt
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