Dataset Information


Gene expression changes in C57Bl/6 and CD16-/- murine bone-marrow derived dendritic cells (BMDCs) following overnight stimulation with OVA or OVA-immune complex

ABSTRACT: Atopic asthma is a chronic inflammatory disease of the lungs that is commonly associated with a Th2 response. The role of allergen-specific IgG in the initiation and development of allergic airway inflammation is still poorly understood; however, a receptor of IgG-immune complexes, CD16, has been demonstrated to promote augmentation of Th2 responses. To identify what genes downstream of CD16 signaling may be contributing to development of a Th2 response, we use ovalbumin (OVA) as our model antigen and compared wildtype and CD16-/- BMDCs that were treated overnight with OVA or OVA-immune complex. C57Bl/6 and CD16-/- BMDCs were treated for 24 hours with OVA or OVA-immune complex and then analyzed for gene expression changes.

ORGANISM(S): Mus musculus  

SUBMITTER: Melissa Yuwono Tjota   Anne I Sperling 

PROVIDER: E-GEOD-44388 | ArrayExpress | 2013-02-20



Similar Datasets

2008-06-27 | E-GEOD-7481 | ArrayExpress
2019-01-17 | PXD006400 | Pride
2011-08-25 | E-MEXP-3119 | ArrayExpress
2013-03-22 | E-GEOD-31949 | ArrayExpress
2012-05-02 | E-GEOD-33718 | ArrayExpress
2011-06-10 | E-MEXP-3118 | ArrayExpress
2015-07-15 | E-GEOD-49694 | ArrayExpress
2012-12-31 | E-GEOD-28168 | ArrayExpress
2015-04-30 | E-GEOD-68420 | ArrayExpress
2008-06-27 | GSE7481 | GEO