Transcriptomics

Dataset Information

3

Gene expression changes in C57Bl/6 and CD16-/- murine bone-marrow derived dendritic cells (BMDCs) following overnight stimulation with OVA or OVA-immune complex


ABSTRACT: Atopic asthma is a chronic inflammatory disease of the lungs that is commonly associated with a Th2 response. The role of allergen-specific IgG in the initiation and development of allergic airway inflammation is still poorly understood; however, a receptor of IgG-immune complexes, CD16, has been demonstrated to promote augmentation of Th2 responses. To identify what genes downstream of CD16 signaling may be contributing to development of a Th2 response, we use ovalbumin (OVA) as our model antigen and compared wildtype and CD16-/- BMDCs that were treated overnight with OVA or OVA-immune complex. C57Bl/6 and CD16-/- BMDCs were treated for 24 hours with OVA or OVA-immune complex and then analyzed for gene expression changes.

ORGANISM(S): Mus musculus  

SUBMITTER: Melissa Yuwono Tjota   Anne I Sperling 

PROVIDER: E-GEOD-44388 | ArrayExpress | 2013-02-20

SECONDARY ACCESSION(S): GSE44388PRJNA189719

REPOSITORIES: GEO, ArrayExpress

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