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Global DNA Methylation Remodeling Accompanies CD8 T Cell Effector Function

ABSTRACT: In response to acute infection CD8 T cells differentiate into effector cells capable of clearing the antigen. While the transcriptional and functional changes have previously been studied little is known of the epigenetic modifications that accompany this differentiation process. To gain insights into CD8 T cell effector differentiation and the role of epigenetics, we mapped DNA methylation by MeDIP-seq in naive CD8 T cells and day 8 effector CD8 T cells that are induced following an acute infection. We identified hundreds of thousands of differentially methylated regions (DMRs). Promoter DNA methylation inversely correlated with gene expression and DMRs were enriched for functional transcription factor binding sites. These data indicated that DNA methylation is dynamic during CD8 T cell differentiation and provide a map of possible regulatory regions important in this process. Examination of DNA methylation during CD8 T cell differentiation from naïve to day 8 effectors following acute infection

ORGANISM(S): Mus musculus  

SUBMITTER: J M Boss   Chris Scharer  C D Scharer 

PROVIDER: E-GEOD-44638 | ArrayExpress | 2013-08-18



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Global DNA methylation remodeling accompanies CD8 T cell effector function.

Scharer Christopher D CD   Barwick Benjamin G BG   Youngblood Benjamin A BA   Ahmed Rafi R   Boss Jeremy M JM  

Journal of immunology (Baltimore, Md. : 1950) 20130816 6

The differentiation of CD8 T cells in response to acute infection results in the acquisition of hallmark phenotypic effector functions; however, the epigenetic mechanisms that program this differentiation process on a genome-wide scale are largely unknown. In this article, we report the DNA methylomes of Ag-specific naive and day-8 effector CD8 T cells following acute lymphocytic choriomeningitis virus infection. During effector CD8 T cell differentiation, DNA methylation was remodeled such that  ...[more]

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