Genomics

Dataset Information

5

Global DNA Methylation Remodeling Accompanies CD8 T Cell Effector Function

ABSTRACT: In response to acute infection CD8 T cells differentiate into effector cells capable of clearing the antigen. While the transcriptional and functional changes have previously been studied little is known of the epigenetic modifications that accompany this differentiation process. To gain insights into CD8 T cell effector differentiation and the role of epigenetics, we mapped DNA methylation by MeDIP-seq in naive CD8 T cells and day 8 effector CD8 T cells that are induced following an acute infection. We identified hundreds of thousands of differentially methylated regions (DMRs). Promoter DNA methylation inversely correlated with gene expression and DMRs were enriched for functional transcription factor binding sites. These data indicated that DNA methylation is dynamic during CD8 T cell differentiation and provide a map of possible regulatory regions important in this process. Examination of DNA methylation during CD8 T cell differentiation from naïve to day 8 effectors following acute infection

ORGANISM(S): Mus musculus  

SUBMITTER: J M Boss   Chris Scharer  C D Scharer 

PROVIDER: E-GEOD-44638 | ArrayExpress | 2013-08-18

SECONDARY ACCESSION(S): SRP018844GSE44638PRJNA191093

REPOSITORIES: GEO, ArrayExpress, ENA

Json Xml

Dataset's files

Source:
Action DRS
E-GEOD-44638.additional.1.zip Other
E-GEOD-44638.idf.txt Idf
E-GEOD-44638.processed.1.zip Processed
E-GEOD-44638.processed.2.zip Processed
E-GEOD-44638.processed.3.zip Processed
Items per page:
1 - 5 of 6
altmetric image

Publications

Global DNA methylation remodeling accompanies CD8 T cell effector function.

Scharer Christopher D CD   Barwick Benjamin G BG   Youngblood Benjamin A BA   Ahmed Rafi R   Boss Jeremy M JM  

Journal of immunology (Baltimore, Md. : 1950) 20130816 6

The differentiation of CD8 T cells in response to acute infection results in the acquisition of hallmark phenotypic effector functions; however, the epigenetic mechanisms that program this differentiation process on a genome-wide scale are largely unknown. In this article, we report the DNA methylomes of Ag-specific naive and day-8 effector CD8 T cells following acute lymphocytic choriomeningitis virus infection. During effector CD8 T cell differentiation, DNA methylation was remodeled such that  ...[more]

Similar Datasets

Transcriptomics Transcription profiling of mouse IL-7Rhi/lo effector CD8 T cells on day 6/7 after LCMV armstrong infection
2008-06-16 | E-GEOD-8678 | ArrayExpress
Genomics De novo DNA methylation by DNA Methyltransferase 3a controls early effector CD8+ T cell fate decisions following activation
2016-08-20 | E-GEOD-85823 | ArrayExpress
Transcriptomics,Multiomics Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life
2014-05-13 | E-GEOD-56575 | ArrayExpress
Transcriptomics Transcription profiling of mouse naive, effector, memory and exhausted virus-specific CD8 T cells after chronic viral infection
2008-06-16 | E-GEOD-9650 | ArrayExpress
Transcriptomics Expression data for naïve IL-2 and IL-12 primed Pmel-1 CD8+ T-cells
2010-10-19 | E-GEOD-22443 | ArrayExpress
Transcriptomics Whole mouse genome analysis of LCMV-specific CD4 and CD8 T cells throughout acute and chronic LCMV infection.
2012-12-12 | E-GEOD-30431 | ArrayExpress
Transcriptomics,Multiomics Longitudinal expression data from CD8+ T cells responding to LCMV-Armstrong or LCMV-Clone 13
2012-11-23 | E-GEOD-41867 | ArrayExpress
Transcriptomics Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells
2015-06-22 | E-GEOD-66421 | ArrayExpress
Transcriptomics Differential expression of mRNAs in naïve, effector, and memory CD8 T cells of mir-150 KO and wild-type mice
2014-10-11 | E-GEOD-62262 | ArrayExpress
Transcriptomics Pd-1 High and Intermediate CD8+ T cells
2014-10-24 | E-GEOD-41869 | ArrayExpress