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Interleukin-27 is a potent inhibitor of cis HIV-1 replication in Monocyte-derived Dendritic Cells via a Type I Interferon-independent pathway

ABSTRACT: IL-27 treated DCs were shown to be highly potent inhibitors of cis HIV-1, particularly of CCR5 tropic strains. Microarray studies of IL-27 treated DCs showed no up-regulation of Type I (IFN) gene expression. Neutralization of the Type-I IFN receptor had no impact on the HIV inhibition. Lastly, IL-27 mediated inhibition was shown to act post-viral entry and prior to completion of reverse transcription. These results show for the first time that IL-27 is a potent inhibitor of cis HIV-1 infection in DCs by a Type I IFN independent mechanism. Gene expression microarrays from 3 samples of immature dendritic cells (iDCs) were compared with 3 samples of iDCs treated with IL-27

ORGANISM(S): Homo sapiens  

SUBMITTER: Richard A Lempicki   Tomozumi Imamichi  Sanjay Swaminathan  Qian Chen 

PROVIDER: E-GEOD-44732 | ArrayExpress | 2013-03-29



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Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway.

Chen Qian Q   Swaminathan Sanjay S   Yang De D   Dai Lue L   Sui Hongyan H   Yang Jun J   Hornung Ronald L RL   Wang Yanmei Y   Huang Da Wei da W   Hu Xiaojun X   Lempicki Richard A RA   Imamichi Tomozumi T  

PloS one 20130320 3

IL-27, a member of the IL-12 family of cytokines, plays an important and diverse role in the function of the immune system. Whilst generally recognized as an anti-inflammatory cytokine, in addition IL-27 has been found to have broad anti-viral effects. Recently, IL-27 has been shown to be a potent inhibitor of HIV-1 infection in CD4+ T cells and macrophages. The main objective of this study was to see whether IL-27 has a similar inhibitory effect on HIV-1 replication in dendritic cells (DCs). Mo  ...[more]

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