Transcriptomics

Dataset Information

239

Small RNA profiling of human cumulus cells and oocytes


ABSTRACT: Cumulus cells are biologically distinct from other follicular cells and perform specialized roles, transmitting signals within the ovary and supporting oocyte maturation during follicular development. The bi-directional communication between the oocyte and the surrounding cumulus cells is crucial for the acquisition of oocyte competence. Using Illumina/deep-sequencing technology, we dissected the small RNAome of pooled human mature MII oocytes and cumulus cells. Cumulus cells and MII mature oocytes small RNA profiles were generated by deep-sequencing, using Illumina 1G sequencer

ORGANISM(S): Homo sapiens  

SUBMITTER: Samir Hamamah   Said Assou 

PROVIDER: E-GEOD-44792 | ArrayExpress | 2015-04-10

SECONDARY ACCESSION(S): GSE44792SRP018933PRJNA191821

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

MicroRNAs: new candidates for the regulation of the human cumulus-oocyte complex.

Assou S S   Al-edani T T   Haouzi D D   Philippe N N   Lecellier C-H CH   Piquemal D D   Commes T T   Aït-Ahmed O O   Dechaud H H   Hamamah S S  

Human reproduction (Oxford, England) 20130730 11


STUDY QUESTION: What is the expression pattern of microRNAs (miRNAs) in human cumulus-oocyte complexes (COCs)? SUMMARY ANSWER: Several miRNAs are enriched in cumulus cells (CCs) or oocytes, and are predicted to target genes involved in biological functions of the COC. WHAT IS KNOWN ALREADY: The transcriptional profiles of human MII oocytes and the surrounding CCs are known. However, very limited data are available about post-transcriptional regulators, such as miRNAs. This is the first study foc  ...[more]

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