Transcriptomics

Dataset Information

10

Gene expression from H69M versus H69 SCLC cell lines


ABSTRACT: H69M cells derive from H69 small cell lung cancer cells subjected to prolonged treatment with HGF. Among the whole population of cells, a subset of more fibroblastic cells was isolated (H69M-mesenchymal). In this experiment we compared expression profiles of both cell lines Keywords: Expression Profiling by array We analyzed 3 arrays from each condition:H69 versus H69M SCLC cell lines

REANALYSED by: E-GEOD-45120

ORGANISM(S): Homo sapiens  

SUBMITTER: Edurne Arriola   EDURNE ARRIOLA  Israel Cañadas 

PROVIDER: E-GEOD-45120 | ArrayExpress | 2013-12-31

SECONDARY ACCESSION(S): GSE45120PRJNA193082

REPOSITORIES: GEO, ArrayExpress

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Publications

Targeting epithelial-to-mesenchymal transition with Met inhibitors reverts chemoresistance in small cell lung cancer.

Cañadas Israel I   Rojo Federico F   Taus Álvaro Á   Arpí Oriol O   Arumí-Uría Montserrat M   Pijuan Lara L   Menéndez Silvia S   Zazo Sandra S   Dómine Manuel M   Salido Marta M   Mojal Sergi S   García de Herreros Antonio A   Rovira Ana A   Albanell Joan J   Arriola Edurne E  

Clinical cancer research : an official journal of the American Association for Cancer Research 20131127 4


Met receptor phosphorylation is associated with poor prognosis in human small cell lung cancer (SCLC). The aim of our work was to investigate the effects of hepatocyte growth factor (HGF)/Met-mediated epithelial-to-mesenchymal transition (EMT) in SCLC and to evaluate the role of Met inhibition in mesenchymal/chemorefractory SCLC models.SCLC models of HGF-induced EMT were evaluated in vitro and in vivo (subcutaneous xenografts in BALB/c nude mice) for chemosensitivity and response to Met inhibiti  ...[more]

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