Transcriptomics

Dataset Information

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Gene Expression Test for Operational Renal Allograft Tolerance


ABSTRACT: Genomic Analysis of more than 400 patients from multi-center transplant programs and clinical trials provides a non-invasive QPCR based gene expression test for operational renal allograft tolerance 3 group comparison of blood from TOL, CAN and Non-transplant healthy controls (HD) allografts. Biological replicates: 16 TOL, 10 CAN and 5 HC

ORGANISM(S): Homo sapiens  

SUBMITTER: Sam Strober   Matthew James Vitalone  Michael Alonso  Oscar Salvatierra  Adriana Zeevi  Josefina Alberu  Minnie Sarwal  Matthew Vitalone  Ed Engelman  Hong Dai  Tara Sigdel  Silke Roedder  Szu-chuan Hsieh  Minh-thien Vu  Li Li 

PROVIDER: E-GEOD-45218 | ArrayExpress | 2015-01-08

SECONDARY ACCESSION(S): GSE45218PRJNA215714

REPOSITORIES: GEO, ArrayExpress

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Publications


Organ transplant recipients face life-long immunosuppression and consequently are at high risk of comorbidities. Occasionally, kidney transplant recipients develop a state of targeted immune quiescence (operational tolerance) against an HLA-mismatched graft, allowing them to withdraw all immunosuppression and retain stable graft function while resuming immune responses to third-party antigens. Methods to better understand and monitor this state of alloimmune quiescence by transcriptional profili  ...[more]

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