Dataset Information


Inhibition of Lymphotoxin-LIGHT Signaling Reduces the Interferon Signature in Rheumatoid Arthritis Patients

ABSTRACT: Whole blood expression was profiled in Rheumatoid Arthiritis and SLE (Systemic LUPUS Erythomatosus) patients. Expression in the whole blood of RA and SLE patients, comparing gene expression signatures in SLE, and RA DMARD-IR and RA TNF-IR patients. This is baseline whole blood expression data for 3 patient populations (SLE, RA DMARD-IR and RA TNF-IR) and 20 Controls.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jeff Browning   Jadwiga Bienkowska  Norm Allaire 

PROVIDER: E-GEOD-45291 | ArrayExpress | 2015-05-14



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A subset of patients with autoimmune diseases including rheumatoid arthritis (RA) and lupus appear to be exposed continually to interferon (IFN) as evidenced by elevated expression of IFN induced genes in blood cells. In lupus, detection of endogenous chromatin complexes by the innate sensing machinery is the suspected driver for the IFN, but the actual mechanisms remain unknown in all of these diseases. We investigated in two randomized clinical trials the effects on RA patients of baminercept,  ...[more]

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