Dataset Information


Examination of the MAPK pathway gene expression in patient samples

ABSTRACT: Microarray analysis of total RNA isolated from samples of circulating tumor cells from 7 patients before romidepsin infusion (0 hours), at 4 h after initiation of the infusion (4 hours) and 24 h after initiation of the infusion (24 hours). MAPK pathway related genes were selected to see differences between patient blood samples after roomidepsin treatment at 0 hour, 4 hour and 24 hour.

ORGANISM(S): Homo sapiens  

SUBMITTER: Z Zhan   AR Chakraborty  AV Kossenkov  J Gillet  LC Showe  MM Gottesman  SE Bates  RW Robey  Louise C Showe  NL Collie  RL Piekarz  J Wilkerson  VL Luchenko 

PROVIDER: E-GEOD-45405 | ArrayExpress | 2013-06-03



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MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor.

Chakraborty Arup R AR   Robey Robert W RW   Luchenko Victoria L VL   Zhan Zhirong Z   Piekarz Richard L RL   Gillet Jean-Pierre JP   Kossenkov Andrew V AV   Wilkerson Julia J   Showe Louise C LC   Gottesman Michael M MM   Collie Nathan L NL   Bates Susan E SE  

Blood 20130326 20

To identify molecular determinants of histone deacetylase inhibitor (HDI) resistance, we selected HuT78 cutaneous T-cell lymphoma (CTCL) cells with romidepsin in the presence of P-glycoprotein inhibitors to prevent transporter upregulation. Resistant sublines were 250- to 385-fold resistant to romidepsin and were resistant to apoptosis induced by apicidin, entinostat, panobinostat, belinostat, and vorinostat. A custom TaqMan array identified increased insulin receptor (INSR) gene expression; imm  ...[more]

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