Transcriptomics

Dataset Information

8

Examination of the MAPK pathway gene expression in patient samples


ABSTRACT: Microarray analysis of total RNA isolated from samples of circulating tumor cells from 7 patients before romidepsin infusion (0 hours), at 4 h after initiation of the infusion (4 hours) and 24 h after initiation of the infusion (24 hours). MAPK pathway related genes were selected to see differences between patient blood samples after roomidepsin treatment at 0 hour, 4 hour and 24 hour.

ORGANISM(S): Homo sapiens  

SUBMITTER: Z Zhan   AR Chakraborty  AV Kossenkov  J Gillet  LC Showe  MM Gottesman  SE Bates  RW Robey  Louise C Showe  NL Collie  RL Piekarz  J Wilkerson  VL Luchenko 

PROVIDER: E-GEOD-45405 | ArrayExpress | 2013-06-03

SECONDARY ACCESSION(S): GSE45405PRJNA194116

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor.

Chakraborty Arup R AR   Robey Robert W RW   Luchenko Victoria L VL   Zhan Zhirong Z   Piekarz Richard L RL   Gillet Jean-Pierre JP   Kossenkov Andrew V AV   Wilkerson Julia J   Showe Louise C LC   Gottesman Michael M MM   Collie Nathan L NL   Bates Susan E SE  

Blood 20130326 20


To identify molecular determinants of histone deacetylase inhibitor (HDI) resistance, we selected HuT78 cutaneous T-cell lymphoma (CTCL) cells with romidepsin in the presence of P-glycoprotein inhibitors to prevent transporter upregulation. Resistant sublines were 250- to 385-fold resistant to romidepsin and were resistant to apoptosis induced by apicidin, entinostat, panobinostat, belinostat, and vorinostat. A custom TaqMan array identified increased insulin receptor (INSR) gene expression; imm  ...[more]

Similar Datasets

2010-05-21 | GSE21909 | GEO
2010-06-08 | E-GEOD-21909 | ArrayExpress
2015-09-15 | E-GEOD-21909 | ExpressionAtlas
2010-06-11 | GSE22278 | GEO
2014-07-02 | E-GEOD-47655 | ArrayExpress
2010-06-23 | E-GEOD-22278 | ArrayExpress
2015-09-15 | E-GEOD-22278 | ExpressionAtlas
2008-11-07 | E-GEOD-8615 | ArrayExpress
2008-10-30 | GSE8615 | GEO
2018-05-22 | PXD008143 | Pride