Genomics

Dataset Information

299

DNAseq data from human ovarian carcinoma cell lines subjected to shRNA TRC1.0 library


ABSTRACT: The hallmark of human cancer is heterogeneity, mirroring the complexity of genetic and epigenetic alterations acquired during oncogenesis. We extracted DNA of 14 cultured human ovarian carcinoma cell lines subjected to pooled shRNA screen using TRC 1.0 library, and performed DNAseq. 14 ovarian carcinoma cell lines DNAseq data.

ORGANISM(S): Homo sapiens  

SUBMITTER: QH Miow   Seiichi Mori  Luqman H Abdul Hadi  Tuan Zea Tan  RY Huang  TZ Tan  JP Thiery 

PROVIDER: E-GEOD-45420 | ArrayExpress | 2013-05-21

SECONDARY ACCESSION(S): GSE45420SRP019937PRJNA193675

REPOSITORIES: GEO, ArrayExpress, ENA

altmetric image

Publications


Epithelial ovarian cancer (EOC) is hallmarked by a high degree of heterogeneity. To address this heterogeneity, a classification scheme was developed based on gene expression patterns of 1538 tumours. Five, biologically distinct subgroups - Epi-A, Epi-B, Mes, Stem-A and Stem-B - exhibited significantly distinct clinicopathological characteristics, deregulated pathways and patient prognoses, and were validated using independent datasets. To identify subtype-specific molecular targets, ovarian can  ...[more]

Similar Datasets

| GSE45420 | GEO
2013-05-03 | E-GEOD-39305 | ArrayExpress
1000-01-01 | S-EPMC4848840 | BioStudies
2012-02-10 | E-GEOD-29662 | ArrayExpress
1000-01-01 | S-EPMC545904 | BioStudies
1000-01-01 | S-EPMC2797056 | BioStudies
2015-01-01 | S-EPMC4578898 | BioStudies
1000-01-01 | S-EPMC3419953 | BioStudies
2020-01-01 | S-EPMC7590429 | BioStudies
2012-01-01 | S-EPMC3905744 | BioStudies