Dataset Information


Effects of fluvastatin treatment on monocyte gene expression in SLE patients

ABSTRACT: The present gene expression array study of fluvastatin effects on monocytes from SLE patients show that fluvastatin has a global anti-inflammatory effect on monocytes, which includes attenuated expression of several proinflammatory cytokines, and regulated expression of molecules mediating lipoprotein signaling and cholesterol metabolism, as well as atherosclerosis and inflammatory signaling. Twenty seven SLE patients were given 20mg/day fluvastatin for one month. Blood samples were obtained before the starting of the treatment and at the end of treatment. Total RNA from monocytes was extracted using TRIzol reagent. RNA quality control was performed in a 2100 Bioanalyzer. Complementary RNAs from six SLE patients (four before treatment and two after treatment) were prepared for hybridization in an Agilent G4112F platform (Whole human Genome microarray 44K) using the One-color gene expression system (Agilent technologies).

ORGANISM(S): Homo sapiens  

SUBMITTER: Lopez P Chary   Rosario Lopez Pedrera 

PROVIDER: E-GEOD-45422 | ArrayExpress | 2014-03-12



Dataset's files

Action DRS Other
E-GEOD-45422.idf.txt Idf Processed Raw
E-GEOD-45422.sdrf.txt Txt
Items per page:
1 - 5 of 5

Similar Datasets

2014-03-12 | E-GEOD-50395 | ArrayExpress
2012-06-13 | E-GEOD-38351 | ArrayExpress
2014-06-03 | E-GEOD-46920 | ArrayExpress
2014-06-03 | E-GEOD-46907 | ArrayExpress
2014-01-01 | S-EPMC3986270 | BioStudies
2010-05-06 | E-GEOD-21649 | ArrayExpress
2019-02-18 | PXD011796 | Pride
2017-01-01 | S-EPMC5575977 | BioStudies
2017-01-01 | S-EPMC5589732 | BioStudies
2014-01-01 | S-EPMC4010412 | BioStudies