Transcriptomics

Dataset Information

4

ChIP-DSL H20K promoter array from human gastric cancer cells MKN28 with Sox2 overexpression


ABSTRACT: The transcription factor Sox2 inhibits human gastric cancer growth and activates Sox2-related tumor surpressive genes in human gastric cancer cells. Conditional Sox2-overexpression in cells with a low Sox2 level demonstrated that the Sox2-regulated tumor surpressive genes demand on an enhanced Sox2 activity for better expression to work in human gastric cancer. Chromatin immunoprecipitation (ChIP) of Sox2 together with chromatin profiling by ChIP-on-chip analysis demonstrated that Sox2 directly activates the chromatin at promoters or putative enhancers of Sox2 target genes. Transcription factor Sox2 promoter array in MKN28 cells with Sox2 overexpression.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jun Tie   Wang Simeng  Simeng Wang 

PROVIDER: E-GEOD-45427 | ArrayExpress | 2013-05-22

SECONDARY ACCESSION(S): GSE45427PRJNA193701

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-45427.idf.txt Idf
E-GEOD-45427.processed.1.zip Processed
E-GEOD-45427.raw.1.zip Raw
E-GEOD-45427.sdrf.txt Txt
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