Transcriptomics

Dataset Information

3

Dynamic genome-wide transcriptional response of human monocyte-derived dendritic cells to IL-6 and Il-10


ABSTRACT: Single cell timecourse experiments demonstrated that though IL-6 and IL-10 activate STAT3, they generate different temporal patterns of activation, with IL-6 generating a transient activation of STAT3, and IL-10 generating a sustained STAT3 response. We hypothesized that these different STAT3 activation dynamics would dictate the differing cellular responses to the two cytokines. Human monocyte-derived denditic cells from four different donors were treated with IL-6 or IL-10 for either 0min, 45min, 2hr, 4hr, 8hr, or 12hr. Total RNA was isolated from each sample and used for gene expression analysis.

ORGANISM(S): Homo sapiens  

SUBMITTER: David A Braun   Stuart C Sealfon  David Braun  Miguel Fribourg 

PROVIDER: E-GEOD-45466 | ArrayExpress | 2013-03-26

SECONDARY ACCESSION(S): GSE45466PRJNA194093

REPOSITORIES: GEO, ArrayExpress

Similar Datasets

2015-11-05 | E-GEOD-74262 | ArrayExpress
2020-05-12 | PXD016245 | Pride
2013-12-15 | E-GEOD-52081 | ArrayExpress
2015-07-07 | E-GEOD-61677 | ArrayExpress
2013-03-08 | E-GEOD-42051 | ArrayExpress
2010-03-08 | E-GEOD-18791 | ArrayExpress
2014-11-01 | E-GEOD-41992 | ArrayExpress
2013-12-30 | E-GEOD-26438 | ArrayExpress
2015-09-03 | E-GEOD-18791 | ExpressionAtlas
2013-01-28 | E-GEOD-15036 | ArrayExpress