Transcriptomics

Dataset Information

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Genome-wide analysis of SIK2 regulated genes and pathways


ABSTRACT: Identification of SIK2 regulated genes and pathways after SIK2 knock-down and overexpression of a wild-type and kinase-dead SIK2. The hypothesis is that SIK2 regulated gene expression via CREB1 Total RNAs were obtained after SIK2 gene was knocked down with siRNA and after a wild-type SIK2 or a kinase-dead SIK2 construct were over-expressed in LNCaP cells. A control where the cells were treated with a CREB1 inducer (Forskolin) was also included.

ORGANISM(S): Homo sapiens  

SUBMITTER: Helene Bon   Thomas Carroll  Michelle Osborne  Silvia Halim 

PROVIDER: E-GEOD-45711 | ArrayExpress | 2015-01-12

SECONDARY ACCESSION(S): GSE45711PRJNA195915

REPOSITORIES: GEO, ArrayExpress

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Publications

Salt-inducible kinase 2 regulates mitotic progression and transcription in prostate cancer.

Bon Hélène H   Wadhwa Karan K   Schreiner Alexander A   Osborne Michelle M   Carroll Thomas T   Ramos-Montoya Antonio A   Ross-Adams Helen H   Visser Matthieu M   Hoffmann Ralf R   Ahmed Ahmed Ashour AA   Neal David E DE   Mills Ian G IG  

Molecular cancer research : MCR 20141229 4


Salt-inducible kinase 2 (SIK2) is a multifunctional kinase of the AMPK family that plays a role in CREB1-mediated gene transcription and was recently reported to have therapeutic potential in ovarian cancer. The expression of this kinase was investigated in prostate cancer clinical specimens. Interestingly, auto-antibodies against SIK2 were increased in the plasma of patients with aggressive disease. Examination of SIK2 in prostate cancer cells found that it functions both as a positive regulato  ...[more]

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