Transcriptomics

Dataset Information

3

Expression data from MALD1 and MCL cases


ABSTRACT: Patients with conventional mantle cell lymphoma (MCL) show an aggressive clinical behavior. However, cases fulfilling the WHO criteria for MCL, but that remain asymptomatic without treatment, have been reported. In an attempt to understand this heterogeneity, we have compared 17 typical cases of MCL with a homogeneous group of 13 asymptomatic individuals with monoclonal expansion of t(11;14)(q13;q32) cyclin D1-positive B-cells in peripheral blood (MALD1). None of these cases have received treatment (minimum follow-up of 26 months; median, 71 months). Gene expression analysis has shown enrichment of signatures associated to neoplastic behavior and cell proliferation in MCL but not in MALD1. In contrast, MALD1 was highly enriched in gene sets related to immune activation and inflammatory responses. CD38 and CD200 genes were differentially expressed between MCL and MALD1. The combined assessment of both proteins by flow cytometry allowed classifying 85% of MALD1 cases. In summary, we have shown for the first time that MALD1, in contrast to MCL, is characterized by immune activation and driven by inflammatory cues. We have also shown that CD38 and CD200 flow cytometry assessment is useful to discern most cases of MALD1 from MCL in the clinical setting. MALD1 should be identified and segregated from the current MCL category to avoid overdiagnosis and unnecessary treatment. 18 samples were analyzed: 5 MALD1, 5 MCL and 8 Healthy Controls

ORGANISM(S): Homo sapiens  

SUBMITTER: Lara Nonell   Blanca Espinet  Sergi Serrano 

PROVIDER: E-GEOD-45717 | ArrayExpress | 2013-12-23

SECONDARY ACCESSION(S): GSE45717PRJNA195935

REPOSITORIES: GEO, ArrayExpress

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Publications

Distinction between asymptomatic monoclonal B-cell lymphocytosis with cyclin D1 overexpression and mantle cell lymphoma: from molecular profiling to flow cytometry.

Espinet Blanca B   Ferrer Ana A   Bellosillo Beatriz B   Nonell Lara L   Salar Antonio A   Fernández-Rodríguez Concepción C   Puigdecanet Eulàlia E   Gimeno Javier J   Garcia-Garcia Mar M   Vela Maria Carmen MC   Luño Elisa E   Collado Rosa R   Navarro José Tomás JT   de la Banda Esmeralda E   Abrisqueta Pau P   Arenillas Leonor L   Serrano Cristina C   Lloreta Josep J   Miñana Belén B   Cerutti Andrea A   Florensa Lourdes L   Orfao Alberto A   Sanz Ferran F   Solé Francesc F   Dominguez-Sola David D   Serrano Sergio S  

Clinical cancer research : an official journal of the American Association for Cancer Research 20131218 4


According to current diagnostic criteria, mantle cell lymphoma (MCL) encompasses the usual, aggressive variants and rare, nonnodal cases with monoclonal asymptomatic lymphocytosis, cyclin D1-positive (MALD1). We aimed to understand the biology behind this clinical heterogeneity and to identify markers for adequate identification of MALD1 cases.We compared 17 typical MCL cases with a homogeneous group of 13 untreated MALD1 cases (median follow-up, 71 months). We conducted gene expression profilin  ...[more]

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