Transcriptomics

Dataset Information

3

Whole-genome expression data from normal FVB mouse lung tissue, transgenic cyclin E overexpressing (CEO) normal mouse lung tissue, and transgenic CEO lung adenocarcinomas


ABSTRACT: FVB mice were engineered to express wild-type human cyclin E under control of the human surfactant C promoter (CEO mice; Ma et al, PNAS 2007). These mice develop spontaneous lung tumors, which were shown to be adenocarcinoma by histological analysis. Here we compare whole-genome RNA expression levels between the tumors and normal lung of 4 CEO mice as well as 4 nontransgenic animals. RNA was isolated from the lungs of 4 FVB mice and adjacent normal and tumor tissue from 4 FVB transgenes harboring human surfactant protein C- driven wild-type human cyclin E, all 7-11 months in age. These samples were divided into 3 groups of four, and 12 independent hybridizations were performed for analysis with Affymetrix GeneChip Mouse 430 2.0 arrays.

ORGANISM(S): Mus musculus  

SUBMITTER: Alexander M Busch   Sarah Freemantle  Sarah J Freemantle 

PROVIDER: E-GEOD-45744 | ArrayExpress | 2013-04-04

SECONDARY ACCESSION(S): GSE45744PRJNA196156

REPOSITORIES: GEO, ArrayExpress

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