Transcriptomics

Dataset Information

6

Early pig response to experimental infection with Actinobacillus pleuropneomuniae


ABSTRACT: The objective of this study was to identify porcine genes which expression was affected by experimental infection with A. pleuropneumoniae within 24 hours after experimental challenge. Microarray experiments were conducted to reveal genes being significantly differentially expressed in infected versus non-infected lung tissue and in liver and lung lymph node tissue from three challenged versus two non-challenged animals. Keywords: Host response Three comparisons were done: - infected versus non-infected lung tissue sampled from three challenged pigs - liver tissue from three challenged versus two non-challenged animals - lung lymph node tissue from three challenged versus two non-challenged animals All experiments were conducted as common reference design.

ORGANISM(S): Sus scrofa  

SUBMITTER: Jakob Hedegaard   Peter M Heegaard   Kerstin Skovgaard  Tim K Jensen  Henrik Hornshøj  Peter Sørensen  Christian M Bendixen  Shila Mortensen 

PROVIDER: E-GEOD-4577 | ArrayExpress | 2010-06-11

SECONDARY ACCESSION(S): GSE4577PRJNA94417

REPOSITORIES: GEO, ArrayExpress

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Publications

Molecular characterisation of the early response in pigs to experimental infection with Actinobacillus pleuropneumoniae using cDNA microarrays.

Hedegaard Jakob J   Skovgaard Kerstin K   Mortensen Shila S   Sørensen Peter P   Jensen Tim K TK   Hornshøj Henrik H   Bendixen Christian C   Heegaard Peter M H PM  

Acta veterinaria Scandinavica 20070427


BACKGROUND: The bacterium Actinobacillus pleuropneumoniae is responsible for porcine pleuropneumonia, a widespread, highly contagious and often fatal respiratory disease of pigs. The general porcine innate immune response after A. pleuropneumoniae infection is still not clarified. The objective of this study was hence to characterise the transcriptional response, measured by using cDNA microarrays, in pigs 24 hours after experimental inoculation with A. pleuropneumoniae. METHODS: Microarray anal  ...[more]

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