Transcriptomics

Dataset Information

3

MiRNA profiling in HEV71-infected SH-SY5Y cells


ABSTRACT: MicroRNA (miRNA) has been highlighted in pathogen-host interactions, however, little is known about roles of miRNAs in neurological pathogenesis of human enterovirus 71 (HEV71) infections. In this study, the comprehensive miRNA expression profiling in HEV71-infected human neuroblastoma SH-SY5Y cells were performed to identify cellular miRNAs response to HEV71. A total of 69 miRNAs were differentially expressed in HEV71-infected SH-SY5Y cells compared to non-infected cells. These findings provide new information on the miRNA and mRNA profiles in HEV71 infection, which may serve as a basis for further investigation into the biological functions of miRNAs in the neurological pathogenesis of HEV71 infections. Human neuroblastoma SH-SY5Y cells were infected with HEV71. After infection, the cells were harvested and extracted total RNA for miRNA profiling by hybridization on Affymetrix microarrays. A total of 69 miRNAs were differentially expressed inHEV71-infected SH-SY5Y cells compared to non-infected cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: LiJuan Xu   ChengFeng Qin  li juan 

PROVIDER: E-GEOD-45816 | ArrayExpress | 2014-07-31

SECONDARY ACCESSION(S): GSE45816PRJNA197501

REPOSITORIES: GEO, ArrayExpress

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