Transcriptomics

Dataset Information

3

Small RNA expression signatures of gastrointestinal stromal tumors: associations to imatinib resistance and patient outcome


ABSTRACT: We performed miRNA expression profiling in a series of fresh-frozen neoadjuvantly imatinib treated gastrointestinal stromal tumors (GIST), using a microarray approach. Significant differentially expressed miRNAs among imatinib-resistant and imatinib-sensitive groups were identified using SAM analysis. Agilent microarray platform with probes matching 903 human miRNAs was used to determine miRNA expression profiles in 17 GISTs (imatinib-sensitive and 7 imatinib-resistant). To validate the microarray platform, the expression levels of selected miRNAs were evaluated using qRT-PCR.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jan Åhlen   Mehran Ghaderi  Stefano Caramuta  Robert Bränström  Pinar Akçakaya  Catharina Larsson  Arne Östman  Pinar Akcakaya  Erik Berglund  Weng-Onn Lui 

PROVIDER: E-GEOD-45901 | ArrayExpress | 2013-04-10

SECONDARY ACCESSION(S): GSE45901PRJNA196633

REPOSITORIES: GEO, ArrayExpress

Similar Datasets

2015-08-01 | E-GEOD-63159 | ArrayExpress
2014-01-27 | E-GEOD-42906 | ArrayExpress
2010-04-21 | E-GEOD-19387 | ArrayExpress
2011-06-01 | E-GEOD-22816 | ArrayExpress
1000-01-01 | S-EPMC3751646 | BioStudies
1000-01-01 | S-EPMC3138741 | BioStudies
2012-01-01 | S-EPMC3992119 | BioStudies
1000-01-01 | S-EPMC6090611 | BioStudies
2003-11-30 | E-MEXP-21 | ArrayExpress
2010-05-16 | E-GEOD-17775 | ArrayExpress