Transcriptomics

Dataset Information

6

Rat MeDIP Array, naïve, epileptic, and adenosine treated


ABSTRACT: Epilepsy causes altered gene expression; transient adenosine treatment inhibits progression of epileptogenesis Hippocampus of epileptic rat is hypermethylated compared to naïve; adenosine treatment causes hypomethylation Metylation state in epileptic rats (9 weeks post kainic acid induced status epilepticus) was compared to naïve (untreated) rats and epileptic rats treated with adenosine for 5 days

ORGANISM(S): Rattus rattus  

SUBMITTER: Theresa A Lusardi   Detlev Boison 

PROVIDER: E-GEOD-45932 | ArrayExpress | 2013-09-05

SECONDARY ACCESSION(S): GSE45932PRJNA196682

REPOSITORIES: GEO, ArrayExpress

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Publications

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.

Williams-Karnesky Rebecca L RL   Sandau Ursula S US   Lusardi Theresa A TA   Lytle Nikki K NK   Farrell Joseph M JM   Pritchard Eleanor M EM   Kaplan David L DL   Boison Detlev D  

The Journal of clinical investigation 20130725 8


Epigenetic modifications, including changes in DNA methylation, lead to altered gene expression and thus may underlie epileptogenesis via induction of permanent changes in neuronal excitability. Therapies that could inhibit or reverse these changes may be highly effective in halting disease progression. Here we identify an epigenetic function of the brain's endogenous anticonvulsant adenosine, showing that this compound induces hypomethylation of DNA via biochemical interference with the transme  ...[more]

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