Dataset Information


MiRNA expression profiles of cloned CD4+ and CD8+ T cells infected or not by HTLV-1 in vivo

ABSTRACT: To address whether changes in miRNA expression accompany cell-associated replication of HTLV-1 in vivo, we carried out the miRNA expression profiling of CD4+ and CD8+ T-cells derived from naturally HTLV-1 infected individuals with no clinical sign of malignancy. T-cell clones were obtained by limiting dilution culture of PBMCs of HTLV-1 carriers. miRNA expression was assessed by Agilent V3 miRNA array according to the manufacturer's instructions. miRNA expression profiles of cloned CD4+ and CD8+ T-cells (carrying or not HTLV-1) derived from naturally HTLV-1 infected individuals.

ORGANISM(S): Homo sapiens  

SUBMITTER: Franck Mortreux   Céline Vernin 

PROVIDER: E-GEOD-46345 | ArrayExpress | 2014-12-03



altmetric image


HTLV-1 bZIP factor HBZ promotes cell proliferation and genetic instability by activating OncomiRs.

Vernin Céline C   Thenoz Morgan M   Pinatel Christiane C   Gessain Antoine A   Gout Olivier O   Delfau-Larue Marie-Hélène MH   Nazaret Nicolas N   Legras-Lachuer Catherine C   Wattel Eric E   Mortreux Franck F  

Cancer research 20140909 21

Viruses disrupt the host cell microRNA (miRNA) network to facilitate their replication. Human T-cell leukemia virus type I (HTLV-1) replication relies on the clonal expansion of its host CD4(+) and CD8(+) T cells, yet this virus causes adult T-cell leukemia/lymphoma (ATLL) that typically has a CD4(+) phenotype. The viral oncoprotein Tax, which is rarely expressed in ATLL cells, has long been recognized for its involvement in tumor initiation by promoting cell proliferation, genetic instability,  ...[more]

Similar Datasets

2013-06-01 | E-GEOD-38537 | ArrayExpress
2013-05-08 | E-GEOD-26150 | ArrayExpress
| GSE26150 | GEO
2012-02-23 | E-GEOD-31629 | ArrayExpress
2009-08-20 | E-GEOD-17718 | ArrayExpress
2009-08-20 | GSE17718 | GEO
2012-01-01 | E-GEOD-29333 | ArrayExpress
| GSE73170 | GEO
| GSE73169 | GEO
2015-11-01 | E-GEOD-52244 | ArrayExpress