Transcriptomics

Dataset Information

3

Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma


ABSTRACT: We devised a high-throughput, cell-based assay to identify novel therapeutic compounds to treat Group3 medulloblastoma (G3 MB). Mouse G3 MBs, grown as neurospheres, were screened against a library of approximately 7,000 compounds including FDA-approved drugs. We identified two FDA-approved drugs, pemetrexed and gemcitabine that preferentially inhibited tumor proliferation in vitro compared to control neurospheres, and substantially inhibited tumor proliferation in vivo. When combined, the two drugs significantly increased survival P7 Trp53-/-, Cdkn2c-/- neurospheres and MYC mouse cells were compared treated and untreated with drugs pemetrexed+gemcitabine

ORGANISM(S): Mus musculus  

SUBMITTER: Clinton Stewart   Megan Jacus  Sarah Robinson  Anang Shelat  Kip Guy  Marie Morfouace  David Turner  Laure Bihannic  Frederique Zindy  Amar Gajjar  Stephanie Puget  David Finkelstein  Olivier Ayrault  Michael Wang  Martine F Roussel  Xiao-Nan Li  Burgess B Freeman III  Giles W Robinson 

PROVIDER: E-GEOD-46406 | ArrayExpress | 2014-04-15

SECONDARY ACCESSION(S): GSE46406PRJNA200287

REPOSITORIES: GEO, ArrayExpress

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Publications


We devised a high-throughput, cell-based assay to identify compounds to treat Group3 medulloblastoma (G3 MB). Mouse G3 MBs neurospheres were screened against a library of approximately 7,000 compounds including US Food and Drug Administration-approved drugs. We found that pemetrexed and gemcitabine preferentially inhibited G3 MB proliferation in vitro compared to control neurospheres and substantially inhibited G3 MB proliferation in vivo. When combined, these two drugs significantly increased s  ...[more]

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