Transcriptomics

Dataset Information

2

Contribution of CBX4 to cumulus oophorus cell phenotype in mice, and attendant effects in cumulus cell cloned embryos


ABSTRACT: Cumulus oophorus cells play an essential role in oocyte development. CBX4 is a member of the Polycomb complex, which plays a role in regulating cellular differentiation. We used siRNA mediated knockdown of Cbx4 expression followed by Affymetrix array analysis to evaluate the role of CBX4 in cumulus cell differentiated state.

ORGANISM(S): Mus musculus  

SUBMITTER: Lanping Hao   Uros Midic  Judith Garriga  Keith E Latham 

PROVIDER: E-GEOD-46565 | ArrayExpress | 2014-04-29

SECONDARY ACCESSION(S): GSE46565PRJNA200970

REPOSITORIES: GEO, ArrayExpress

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Publications

Contribution of CBX4 to cumulus oophorus cell phenotype in mice and attendant effects in cumulus cell cloned embryos.

Hao Lanping L   Midic Uros U   Garriga Judith J   Latham Keith E KE  

Physiological genomics 20131126 2


Cumulus oophorus cells play an essential role in oocyte development. They are also widely employed as donor cells for cloning by somatic cell nuclear transfer. Our previous studies revealed that Cbx4 mRNA was overexpressed in cloned two-cell embryos. These data indicated that CBX4 may regulate normal cumulus cell differentiation and that its overexpression in clones could contribute to aberrant gene regulation. We used siRNA-mediated knockdown of Cbx4 to assess its role in determining cumulus ce  ...[more]

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