Transcriptomics

Dataset Information

5

In Vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Philmo Oh   Iannis Aifantis  Camille Lobry 

PROVIDER: E-GEOD-46726 | ArrayExpress | 2013-07-01

SECONDARY ACCESSION(S): GSE46726PRJNA202108

REPOSITORIES: GEO, ArrayExpress

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Publications


Accumulating evidence suggests that Notch signaling is active at multiple points during hematopoiesis. Until recently, the majority of such studies focused on Notch signaling in lymphocyte differentiation and knowledge of individual Notch receptor roles has been limited due to a paucity of genetic tools available. In this manuscript we generate and describe animal models to identify and fate-map stem and progenitor cells expressing each Notch receptor, delineate Notch pathway activation, and per  ...[more]

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